What's a moment from the show that stuck with you, but you feel doesn't get talked about enough?

For me it's the moment that Hurley's CD player stops working. I don't know why the moment was so powerful to me, but it makes me cry every time. And it was such a jarring moment too. I don't know that there has ever been a moment in television or movies that has made me feel the way that scene made me feel. I could talk about it forever really, but it just felt like it was saying "Okay, the honeymoon period is over. Shit's getting real now."